三枝胡椒 A-G：三枝胡椒中的二萜类化合物。

Trigoxyphins A-G: diterpenes from Trigonostemon xyphophylloides.

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, People's Republic of China.

出版信息

J Nat Prod. 2010 Jul 23;73(7):1301-5. doi: 10.1021/np100320h.

DOI:10.1021/np100320h

PMID:20593838

Abstract

Six new oxygenated daphnane-type diterpenoids, trigoxyphins A-F (1-6), a phenanthrene-type diterpenoid, trigoxyphin G (7), and two known compounds were isolated from twigs of Trigonostemon xyphophylloides. Their structures were established using spectroscopic methods. Compounds 1 and 2 exhibited strong cytotoxic activity against HL60 (IC(50): 0.27 and 0.49 microM) and A549 (IC(50): 7.5 and 4.9 microM) tumor cell lines, respectively.

摘要

从细子龙（Trigonostemon xyphophylloides）的嫩枝中分离得到了 6 个新的含氧达玛烷型二萜类化合物，即 trigoxyphins A-F（1-6），一个菲型二萜类化合物 trigoxyphin G（7），以及 2 个已知化合物。通过光谱方法确定了它们的结构。化合物 1 和 2 对 HL60（IC（50）：0.27 和 0.49 μM）和 A549（IC（50）：7.5 和 4.9 μM）肿瘤细胞系表现出较强的细胞毒性。