来自秋枫的两种新二萜类化合物。

Two new diterpenoids from Excoecaria acerifolia.

作者信息

Wu Xing-De, Zhang Lan-Chun, He Juan, Li Gen-Tao, Ding Lin-Fen, Gao Xiu, Dong Liao-Bin, Song Liu-Dong, Li Yan, Zhao Qin-Shi

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.

出版信息

J Asian Nat Prod Res. 2013;15(2):151-7. doi: 10.1080/10286020.2012.757596. Epub 2013 Jan 17.

DOI:10.1080/10286020.2012.757596

PMID:23323987

Abstract

A new tigliane diterpenoid, acerifolin A (1), and a new isopimarane diterpenoid, acerifolin B (2), together with two known compounds, were isolated from Excoecaria acerifolia. Their structures were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. All of the compounds were evaluated for cytotoxicity against five human cancer cell lines with cisplantin as a positive control.

摘要

从变叶海漆中分离出一种新的大戟烷二萜类化合物——变叶海漆素A（1）和一种新的异海松烷二萜类化合物——变叶海漆素B（2），以及两种已知化合物。基于包括一维和二维核磁共振技术在内的光谱方法阐明了它们的结构。以顺铂作为阳性对照，对所有化合物针对五种人类癌细胞系的细胞毒性进行了评估。