从三叶苦中提取到具有抗 HIV 活性的瑞香烷二萜。
Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; Graduate University of Chinese Academy of Sciences, Beijing 100039, People's Republic of China.
出版信息
Phytochemistry. 2013 Dec;96:360-9. doi: 10.1016/j.phytochem.2013.10.005. Epub 2013 Nov 5.
Sixteen daphnane diterpenoids, trigothysoids A-P, along with 15 known ones, were isolated from the methanol extract of the twigs and leaves of Trigonostemon thyrsoideum. Their structures were established by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The anti-HIV-1 activity of the compounds was also evaluated in vitro, and five compounds demonstrated potent anti-HIV-1 activity, with EC50 values of 0.015-0.001 nM and TI values of 1618-17,619.
从细子龙（Trigonostemon thyrsoideum）的小枝和叶的甲醇提取物中分离得到 16 种瑞香烷二萜类化合物，即 trigothysoids A-P，以及 15 种已知化合物。通过广泛的光谱技术，包括 2D NMR 光谱和质谱，确定了它们的结构。还评估了这些化合物的抗 HIV-1 活性，其中 5 种化合物表现出较强的抗 HIV-1 活性，EC50 值为 0.015-0.001 nM，TI 值为 1618-17619。
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