Johnson P D, Graves S R, Stewart L, Warren R, Dwyer B, Lucas C R
Fairfield Infectious Diseases Hospital, Victoria, Australia.
AIDS. 1991 Apr;5(4):419-23. doi: 10.1097/00002030-199104000-00010.
The diagnosis of syphilis is frequently dependent upon the results of serological tests, but the reliability of syphilis serology in patients with HIV-1 infection has been questioned. We examined specific antibody to Treponema pallidum (TP) using the TP haemagglutination (TPHA) and fluorescent treponemal antibody-absorption (FTA-ABS) tests in AIDS patients and HIV-antibody-negative controls with a history of syphilis. Tests were carried out on two sera separated by an interval of at least 3 years from each patient. Twelve out of 29 AIDS patients compared with four out of 29 controls showed significant falls in titres of specific antibody as measured by the TPHA, FTA-ABS, or by both the TPHA and FTA-ABS (P = 0.02). Furthermore, in three out of 29 (10%) of the AIDS patients with past syphilis infections both the TPHA and FTA-ABS became non-reactive. We conclude that negative specific serology does not exclude a past syphilis infection in patients with AIDS.
梅毒的诊断常常依赖于血清学检测结果，但HIV-1感染患者梅毒血清学的可靠性受到了质疑。我们使用梅毒螺旋体血凝试验（TPHA）和荧光密螺旋体抗体吸收试验（FTA-ABS），对有梅毒病史的艾滋病患者和HIV抗体阴性对照者检测了抗梅毒螺旋体（TP）特异性抗体。对每位患者间隔至少3年采集的两份血清进行检测。29例艾滋病患者中有12例，相比之下29例对照者中有4例，通过TPHA、FTA-ABS或两者检测，特异性抗体滴度显著下降（P = 0.02）。此外，29例曾感染梅毒的艾滋病患者中有3例（10%），TPHA和FTA-ABS均变为无反应性。我们得出结论，特异性血清学阴性不能排除艾滋病患者既往感染过梅毒。
