Parkman R
Division of Research Immunology/Bone Marrow Transplantation, Childrens Hospital of Los Angeles, California.
Immunodefic Rev. 1991;2(4):253-64.
The principal clinical problem encountered following allogeneic bone marrow transplantation is acute and chronic graft-versus-host disease. The presence of acute graft-versus-host disease is the strongest predictor for the development of chronic graft-versus-host disease. The introduction of new prophylactic regimens has reduced the incidence of acute graft-versus-host disease. The clinical presentation and pathophysiology of acute and chronic graft-versus-host disease are discussed. New therapies for chronic graft-versus-host disease may result in improved treatment for human autoimmune diseases.
同种异体骨髓移植后遇到的主要临床问题是急性和慢性移植物抗宿主病。急性移植物抗宿主病的存在是慢性移植物抗宿主病发生的最强预测指标。新的预防方案的引入降低了急性移植物抗宿主病的发生率。本文讨论了急性和慢性移植物抗宿主病的临床表现和病理生理学。慢性移植物抗宿主病的新疗法可能会改善人类自身免疫性疾病的治疗。
