Toubai Tomomi, Sun Yaping, Reddy Pavan
Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0942, USA.
Best Pract Res Clin Haematol. 2008 Jun;21(2):101-17. doi: 10.1016/j.beha.2008.02.005.
Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation (HCT). GVHD occurs in acute and chronic forms. Acute GVHD usually manifests within 100 days following HSCT. It is induced by donor T cells responding to the mismatched host polymorphic histocompatibility antigens. Chronic GVHD generally manifests later (>100 days) and has some features of autoimmune diseases. It may develop either de novo or following resolution of - or as an extension of - acute GVHD. Chronic GVHD is also thought to be induced by donor T cells, but the nature of relevant antigens, the critical cellular subsets and the mechanisms of chronic GVHD remain less well understood. In this chapter we briefly discuss and contrast the pathophysiologies of acute and chronic GVHD.
移植物抗宿主病（GVHD）是异基因造血细胞移植（HCT）的主要并发症。GVHD有急性和慢性两种形式。急性GVHD通常在造血干细胞移植（HSCT）后100天内出现。它是由供体T细胞对不匹配的宿主多态性组织相容性抗原作出反应所诱发的。慢性GVHD通常在较晚时间（>100天）出现，具有一些自身免疫性疾病的特征。它可以新发，也可在急性GVHD缓解后发生，或作为急性GVHD的延续而出现。慢性GVHD也被认为是由供体T细胞诱发的，但相关抗原的性质、关键细胞亚群以及慢性GVHD的机制仍了解较少。在本章中，我们简要讨论并对比急性和慢性GVHD的病理生理学。
