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多发性颅内动脉瘤。血管造影研究与血管内治疗。

Multiple intracranial aneurysms. Angiographic study and endovascular treatment.

作者信息

Mont'alverne F, Tournade A, Riquelme C, Musacchio M

机构信息

Interventional Neuroradiology, Centre Hospitalier Louis Pasteur, Colmar; France.

出版信息

Interv Neuroradiol. 2002 Jun 30;8(2):95-106. doi: 10.1177/159101990200800201. Epub 2004 Oct 20.

Abstract

We evaluate endovascular treatment (EVT) as an option to deal with multiple intracranial aneurysms(MA). From 1994 to 2001, 24 patients underwent EVT for 59 MA. Patients were followed- up clinically and angiographically in a period ranging from 6 to 93 months (mean time of 22.2) and from 4 to 69 months (mean time of 19.3), respectively. Ten patients (41.6%) were treated either by EVT (n=7, 29,16%) or by mixed treatment (EVT and surgery; n=3, 12.5%). Reasons for treating just ruptured aneurysms: six (25%) had aneurysms smaller than 5 mm; three (12.5%) deaths; two (8.33%) were in the subacute period; two (8.33%) lost to follow-up; one (4.17%) authorised no procedure. No rebleeding was detected at the clinical follow-up, but there were five deaths.At immediate arteriographic control: 28 (85%) aneurysms were fully occluded, four (12%) with neck flow and one (03%) with sac flow. For 20 aneurysms followed-up: stability of occlusion was reached in seven cases (35%) and repermeabilization in 13 (65%). Management of recanalization was close arteriography in seven (54%), re-embolization in five (38%) and surgery in one (08%). When treating MA, EVT is advisable either alone or in mixed therapy. As a high degree of repermeabilization was disclosed, strict arteriographic control is required. The mechanisms underlying aneurysmal formation may be also involved in the recanalization phenomenon , a possible new manifestation of the fragility of the arterial wall.

摘要

我们评估血管内治疗(EVT)作为处理多发性颅内动脉瘤(MA)的一种选择。1994年至2001年,24例患者因59个MA接受了EVT治疗。分别在6至93个月(平均时间22.2个月)和4至69个月(平均时间19.3个月)期间对患者进行了临床和血管造影随访。10例患者(41.6%)接受了EVT治疗(n = 7,29.16%)或混合治疗(EVT和手术;n = 3,12.5%)。仅治疗破裂动脉瘤的原因:6例(25%)动脉瘤小于5毫米;3例(12.5%)死亡;2例(8.33%)处于亚急性期;2例(8.33%)失访;1例(4.17%)未接受任何治疗。临床随访未发现再出血,但有5例死亡。在即刻血管造影控制时:28个(85%)动脉瘤完全闭塞,4个(12%)有颈部血流,1个(3%)有瘤囊血流。对20个动脉瘤进行随访:7例(35%)达到闭塞稳定,13例(65%)再通。再通的处理方法为密切血管造影7例(54%)、再次栓塞5例(38%)和手术1例(8%)。治疗MA时,单独或联合治疗采用EVT是可取的。由于发现较高程度的再通,需要严格的血管造影控制。动脉瘤形成的潜在机制可能也参与了再通现象,这可能是动脉壁脆弱性的一种新表现形式。

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