De Clercq E, Descamps J, De Somer P, Holý A
Science. 1978 May 5;200(4341).
(S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.
（S）-9-（2,3-二羟基丙基）腺嘌呤是一种新型核苷类似物，其糖部分被脂肪链取代，可在体外抑制多种DNA和RNA病毒的复制，包括牛痘病毒、单纯疱疹病毒（1型和2型）、麻疹病毒和水疱性口炎病毒。它在体内对降低经鼻接种水疱性口炎病毒的小鼠死亡率也有效。
