(S)-9-(2,3-二羟丙基)腺嘌呤：一种具有广谱抗病毒活性的脂肪族核苷类似物。
(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity.
出版信息
Science. 1978 May 5;200(4341):563-5. doi: 10.1126/science.200.4341.563.
PMID:17839440
Abstract
(S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.
摘要
(S)-9-(2,3-二羟丙基)腺嘌呤是一种新型核苷类似物，其糖部分被脂肪链取代，可抑制几种 DNA 和 RNA 病毒的体外复制，包括牛痘、单纯疱疹（1 型和 2 型）、麻疹和水疱性口炎。它在体内也有效，可降低用水疱性口炎病毒滴鼻接种的小鼠的死亡率。
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