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[抗苗勒管激素:卵泡发生的参与者和标志物]

[Anti-Müllerian hormone: player and marker of folliculogenesis].

作者信息

da Silva A-L Berwanger, Even M, Grynberg M, Gallot V, Frydman R, Fanchin R

机构信息

Service de gynécologie-obstétrique et médecine de la reproduction, Inserm U782, hôpital Antoine-Béclère, AP-HP, université Paris-Sud, Clamart, France.

出版信息

Gynecol Obstet Fertil. 2010 Jul-Aug;38(7-8):471-4. doi: 10.1016/j.gyobfe.2010.05.002. Epub 2010 Jul 1.

Abstract

All indicates that anti-Müllerian hormone (AMH), though initially studied for its importance on male development, plays an inhibiting role on the initial and cyclic processes of follicular recruitment. The aspects involved in its regulation are still poorly understood, but the oocyte, some steroids, and follicular development itself seem to be involved. In addition, AMH has become an important clinical marker of ovarian functioning for many reasons, including its exclusive production by granulosa follicles at many stages of development, its probable FSH independence, its low inter and intracycle variability and its reliable quantitative (qualitative?) relationship with ovarian follicles and their response to exogenous FSH. The growing interest in ovarian AMH incited us to review some important fundamental and clinical publications in this field.

摘要

所有迹象表明,抗苗勒管激素(AMH)尽管最初是因其在男性发育中的重要性而被研究,但在卵泡募集的起始和周期性过程中起抑制作用。其调节所涉及的方面仍知之甚少,但卵母细胞、一些类固醇以及卵泡发育本身似乎都与之有关。此外,AMH由于多种原因已成为卵巢功能的重要临床标志物,包括它在许多发育阶段由颗粒卵泡独家产生、可能不依赖促卵泡生成素(FSH)、在周期间和周期内的变异性较低,以及它与卵巢卵泡及其对外源性FSH反应之间可靠的定量(定性?)关系。对卵巢AMH日益增长的兴趣促使我们回顾该领域的一些重要基础和临床出版物。

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