Department of Medical Oncology, London Regional Cancer Program, London, Ontario, Canada.
Department of Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.
Ann Oncol. 2011 Jan;22(1):145-148. doi: 10.1093/annonc/mdq320. Epub 2010 Jul 1.
Temsirolimus is an i.v. administered inhibitor of mammalian target of rapamycin with activity in the first-line setting in poor-prognosis patients with metastatic renal cell carcinoma (RCC). The efficacy of this agent after failure of prior inhibitors of vascular endothelial growth factor (VEGF) is unknown.
a retrospective review of patients with metastatic RCC treated at the Cleveland Clinic Taussig Cancer Institute and three regional cancer centers in Ontario, Canada, through the Torisel (temsirolimus) Compassionate Use Program was conducted. Demographic, toxicity and response data were collected.
a total of 87 patients with metastatic RCC were identified who had previously been treated with inhibitors of VEGF subsequently treated with temsirolimus. The majority of patients had either intermediate or poor-prognosis disease at baseline. Expected toxic effects including hyperglycemia and noninfectious pneumonitis were observed. The RECIST-defined objective response rate was 5% and the stable disease rate was 65%. The median time to progression (TTP) was 3.9 months (95% confidence interval 2.8-4.8 months), and median overall survival was 11.2 months.
in a cohort of pre-treated intermediate to poor-prognosis patients with metastatic RCC, weekly i.v. temsirolimus is associated with predictable, but manageable toxicity, and a TTP approaching 4 months.
替西罗莫司是一种静脉内给药的哺乳动物雷帕霉素靶蛋白抑制剂，在转移性肾细胞癌（RCC）预后不良的患者的一线治疗中具有活性。在血管内皮生长因子（VEGF）抑制剂治疗失败后，该药物的疗效尚不清楚。
通过托瑞塞尔（替西罗莫司）同情使用计划，对在克利夫兰诊所陶西格癌症研究所和加拿大安大略省的三个区域癌症中心接受治疗的转移性 RCC 患者进行了回顾性审查。收集了人口统计学、毒性和反应数据。
共确定了 87 名先前接受过 VEGF 抑制剂治疗随后接受替西罗莫司治疗的转移性 RCC 患者。大多数患者基线时具有中危或预后不良的疾病。观察到预期的毒性作用，包括高血糖和非传染性肺炎。RECIST 定义的客观缓解率为 5%，疾病稳定率为 65%。无进展生存期（TTP）为 3.9 个月（95%置信区间为 2.8-4.8 个月），总生存期为 11.2 个月。
在一组预处理的中危至预后不良的转移性 RCC 患者中，每周静脉内替西罗莫司与可预测但可管理的毒性相关，TTP 接近 4 个月。
