Horsch Sandra, Kutz Patrizia, Roll Claudia
Department of Neonatology, Erasmus Medical Center/Sophia Children's Hospital, Rotterdam, Netherlands.
J Child Neurol. 2010 Jul;25(7):809-14. doi: 10.1177/0883073809346849.
In preterm infants, the germinal matrix is a common origin of hemorrhages during the first 7 days of life. Sonographically, germinal matrix hemorrhages present as subventricular echodensities evolving into pseudocysts. Similar lesions have been reported as incidental findings also beyond 7 days of life. They may result from vasculitis and ischemic infarction, rather than hemorrhage. To assess the occurrence, time course, and significance for neurodevelopment of such late germinal matrix hemorrhage-like lesions, we reviewed serial cerebral ultrasound examinations obtained in 86 sequentially admitted infants (gestational age <32 weeks or birth weight <1500 g). Neurodevelopment was assessed at 3 years (Bayley Scales of Infant Development). Nine infants had late isolated germinal matrix hemorrhage-like lesions. Their Psychomotor Development Index scores were significantly lower than that in infants without hemorrhage. Our results suggest that late isolated germinal matrix hemorrhage-like lesions are of clinical significance because of their notable incidence and association with neurodevelopmental outcome.
在早产儿中，生发基质是出生后7天内出血的常见起源。超声检查时，生发基质出血表现为脑室旁白质回声增强，进而发展为假性囊肿。类似病变在出生7天后也有作为偶然发现的报道。它们可能由血管炎和缺血性梗死引起，而非出血。为评估此类晚期生发基质样出血性病变的发生率、病程及其对神经发育的意义，我们回顾了86例连续入院的婴儿（胎龄<32周或出生体重<1500g）的系列脑部超声检查结果。在3岁时（贝利婴儿发育量表）评估神经发育情况。9例婴儿有晚期孤立性生发基质样出血性病变。他们的心理运动发育指数得分显著低于无出血的婴儿。我们的结果表明，晚期孤立性生发基质样出血性病变因其显著的发生率以及与神经发育结局的关联而具有临床意义。
