Bruni Bresciani V
SOD di Ginecologia dell'Infanzia e dell'Adolescenza, Dipartimento di Scienze per la Salute della Donna e del Bambino, Università di Firenze, Florence, Italy.
Minerva Ginecol. 2010 Jun;62(3):261-6.
Extracontraceptive benefits are common to all oral contraceptives; however, some benefits are more pronounced with particular associations. To improve acne, hirsutism and premenstrual symptoms, for example, oral contraceptives containing drospirenone are more effective. This interesting progestin has marked antiandrogenic and antimineralcorticoid activity. EE/DRSP 24+4 (24 tablets containing hormones plus 4 containing placebo) features an innovative dosing regimen. Shortening of the hormone-free period augments the inhibition of ovulation and reduces fluctuations in hormones, with beneficial effects on withdrawal symptoms, including headache, breast tenderness, mood swings and pelvic pain. Use of EE/DRSP 24+4 for 3 days longer than conventional oral contraceptives also has extracontraceptive benefits, as demonstrated in clinical trials which have evaluated improvement in premenstrual symptoms, acne and hirsutism.
非避孕益处是所有口服避孕药共有的；然而，某些益处与特定组合更为显著。例如，为改善痤疮、多毛症和经前症状，含屈螺酮的口服避孕药更为有效。这种有趣的孕激素具有显著的抗雄激素和抗盐皮质激素活性。炔雌醇/屈螺酮24+4（24片含激素片加4片安慰剂片）具有创新的给药方案。缩短无激素期可增强对排卵的抑制并减少激素波动，对撤退症状有有益影响，包括头痛、乳房压痛、情绪波动和盆腔疼痛。与传统口服避孕药相比，使用炔雌醇/屈螺酮24+4多3天也有非避孕益处，这在评估经前症状、痤疮和多毛症改善情况的临床试验中得到了证明。
