State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Ruijin Second Road 197, Shanghai, China.
J Hum Hypertens. 2011 Jun;25(6):383-90. doi: 10.1038/jhh.2010.68. Epub 2010 Jul 1.
Association of the lipoprotein lipase (LPL) gene S447X variant with hypertension has been investigated extensively, whereas the results are often irreproducible. We therefore conducted a meta-analysis to examine whether S447X variant was associated with hypertension and blood pressure variation. Case-control reports published in English language and humans were identified from MEDLINE, EMBASE and Web of Science search engines as of 10 December 2009. Fixed-effects model was applied to pool data in the absence of between-studies heterogeneity, and random-effects model otherwise. A total of five studies (960 cases and 1145 controls) for hypertension and four studies (n=2777) for blood pressure were included. Compared with 447SS homogeneous carriers, those with 447X variant had a lower risk of hypertension (odds ratio (OR)=0.78; 95% confidence interval (CI): 0.62-0.98; P=0.03), and this effect reached significance under the fixed-effects model (I(2)=30% and P=0.22). Similarly, compared with 447S allele carriers, those with 447X allele carriers also had a lower risk of hypertension (OR=0.79; 95% CI: 0.64-0.98; P=0.03). In case of pregnancy-induced hypertension, no significance was observed (P>0.05). As for blood pressure association, there was no significant difference between 447X variant and 447SS homogeneous carriers for both systolic and diastolic blood pressure in the whole population, even stratified by gender (P>0.05). The Egger test told no publication bias for all associations. This meta-analysis demonstrated that LPL gene S447X variant was significantly associated with hypertension and showed no obvious relation with pregnancy-induced hypertension and blood pressure variation.
脂蛋白脂肪酶（LPL）基因 S447X 变异与高血压的相关性已被广泛研究，但结果往往不可重复。因此，我们进行了荟萃分析，以检验 S447X 变异是否与高血压和血压变化有关。截至 2009 年 12 月 10 日，我们从 MEDLINE、EMBASE 和 Web of Science 搜索引擎中检索到以英语发表的病例对照报告，并以人类为研究对象。如果研究之间没有异质性，则采用固定效应模型汇总数据，如果存在异质性，则采用随机效应模型。共纳入了五项高血压研究（960 例病例和 1145 例对照）和四项血压研究（n=2777）。与 447SS 纯合携带者相比，携带 447X 变异的个体患高血压的风险较低（比值比（OR）=0.78；95%置信区间（CI）：0.62-0.98；P=0.03），且这种效应在固定效应模型下具有统计学意义（I(2)=30%，P=0.22）。同样，与携带 447S 等位基因的个体相比，携带 447X 等位基因的个体患高血压的风险也较低（OR=0.79；95%CI：0.64-0.98；P=0.03）。然而，对于妊娠相关性高血压，未观察到显著差异（P>0.05）。在整个人群中，即使按性别分层，447X 变异与 447SS 纯合携带者之间的收缩压和舒张压均无显著差异（P>0.05）。Egger 检验表明，所有关联均无明显的发表偏倚。这项荟萃分析表明，LPL 基因 S447X 变异与高血压显著相关，与妊娠相关性高血压和血压变化无明显关系。
