Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, PR China.
Hypertens Res. 2010 Nov;33(11):1114-23. doi: 10.1038/hr.2010.151. Epub 2010 Aug 26.
No consensus has been reached on the association between the β2-adrenergic receptor polymorphisms A46G and C79G and essential hypertension risk. We performed a meta-analysis to confirm the possible association. After reviewing 303 reports in PubMed and 359 reports in Embase, we included in our meta-analysis 18 articles (20 studies) that met our inclusion criteria. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. There was no statistical association between A46G and hypertension risk in all subjects, Asians or Caucasians. However, an association was observed in the dominant genetic model (AA vs. (AG+GG)) (P=0.04, odds ratio (OR)=1.38, 95% confidence interval (CI) 1.01-1.87, P(heterogeneity)=0.98, fixed-effects model) in the subgroup of mixed Africans. No overall statistical association could be found between C79G and hypertension risk or any ethnic subgroup. In the research conducted on severe hypertension (systolic blood pressure ≥160 mm Hg and/or diastolic blood pressure ≥95 mm Hg hypertensive population), significant association was found in the dominant genetic model (CC vs. (CG+GG)) (P=0.04, OR=1.38, 95% CI 1.02-1.86, P(heterogeneity)=0.03, random-effects model), and there was also a borderline significance between the C79 allele and severe hypertension (P=0.05, OR=1.26, 95% CI 1.00-1.57, P(heterogeneity)=0.04, random-effects model). No association could be found in this study between the two polymorphisms and stage 2 hypertension. More studies stratified for different ethnicities and different stages of hypertension should be performed in the future.
尚未就β2-肾上腺素能受体多态性 A46G 和 C79G 与原发性高血压风险之间的关联达成共识。我们进行了一项荟萃分析以确认其可能的关联。在 PubMed 中审查了 303 份报告和 Embase 中的 359 份报告后，我们将符合纳入标准的 18 篇文章（20 项研究）纳入荟萃分析。应用固定效应模型和随机效应模型对二分类结局进行合并分析。在所有受试者、亚洲人和高加索人中，A46G 与高血压风险之间均无统计学关联。然而，在混合非洲人亚组中，在显性遗传模型（AA 与（AG+GG））中观察到关联（P=0.04，比值比（OR）=1.38，95%置信区间（CI）1.01-1.87，P（异质性）=0.98，固定效应模型）。未发现 C79G 与高血压风险或任何种族亚组之间存在总体统计学关联。在对重度高血压（收缩压≥160mmHg 和/或舒张压≥95mmHg 的高血压人群）进行的研究中，在显性遗传模型（CC 与（CG+GG））中发现了显著关联（P=0.04，OR=1.38，95%CI 1.02-1.86，P（异质性）=0.03，随机效应模型），并且 C79 等位基因与重度高血压之间也存在边缘显著关联（P=0.05，OR=1.26，95%CI 1.00-1.57，P（异质性）=0.04，随机效应模型）。在本研究中，两个多态性与 2 期高血压之间无关联。未来应针对不同种族和不同阶段的高血压进行更多的分层研究。
