Ríos-González Blanca Estela, Ibarra-Cortés Bertha, Ramírez-López Guadalupe, Sánchez-Corona José, Magaña-Torres María Teresa
División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada No. 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico ; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44348 Guadalajara, JAL, Mexico.
Instituto de Genética Humana "Enrique Corona Rivera", Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44348 Guadalajara, JAL, Mexico.
Dis Markers. 2014;2014:150358. doi: 10.1155/2014/150358. Epub 2014 Dec 21.
Hypertension and dyslipidemia exhibit an important clinical relationship because an increase in blood lipids yields an increase in blood pressure (BP). We analyzed the associations of seven polymorphisms of genes involved in lipid metabolism (APOA5 rs3135506, APOB rs1042031, FABP2 rs1799883, LDLR rs5925, LIPC rs1800588, LPL rs328, and MTTP rs1800591) with blood pressure and lipid values in Mexican hypertensive (HT) patients. A total of 160 HT patients and 160 normotensive individuals were included. Genotyping was performed through PCR-RFLP, PCR-AIRS, and sequencing. The results showed significant associations in the HT group and HT subgroups classified as normolipemic and hyperlipemic. The alleles FABP2 p.55T, LIPC -514T, and MTTP -493T were associated with elevated systolic BP. Five alleles were associated with lipids. LPL p.474X and FABP2 p.55T were associated with decreased total cholesterol and LDL-C, respectively; APOA5 p.19W with increased HDL-C; APOA5 p.19W and FABP2 p.55T with increased triglycerides; and APOB p.4181K and LDLR c.1959T with decreased triglycerides. The APOB p.E4181K polymorphism increases the risk for HT (OR = 1.85, 95% CI: 1.17-2.93; P = 0.001) under the dominant model. These findings indicate that polymorphisms of lipid metabolism genes modify systolic BP and lipid levels and may be important in the development of essential hypertension and dyslipidemia in Mexican HT patients.
高血压和血脂异常呈现出重要的临床关联，因为血脂升高会导致血压（BP）上升。我们分析了参与脂质代谢的7个基因多态性（APOA5 rs3135506、APOB rs1042031、FABP2 rs1799883、LDLR rs5925、LIPC rs1800588、LPL rs328和MTTP rs1800591）与墨西哥高血压（HT）患者的血压和血脂值之间的关联。总共纳入了160例HT患者和160例血压正常个体。通过聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）、聚合酶链反应-等位基因特异性引物延伸法（PCR-AIRS）和测序进行基因分型。结果显示，在HT组以及分为血脂正常和血脂异常的HT亚组中存在显著关联。FABP2 p.55T、LIPC -514T和MTTP -493T等位基因与收缩压升高相关。5个等位基因与血脂相关。LPL p.474X和FABP2 p.55T分别与总胆固醇降低和低密度脂蛋白胆固醇（LDL-C）降低相关；APOA5 p.19W与高密度脂蛋白胆固醇（HDL-C）升高相关；APOA5 p.19W和FABP2 p.55T与甘油三酯升高相关；APOB p.4181K和LDLR c.1959T与甘油三酯降低相关。在显性模型下，APOB p.E4181K多态性增加了患HT的风险（比值比[OR]=1.85，95%置信区间[CI]：1.17 - 2.93；P = 0.001）。这些发现表明，脂质代谢基因的多态性会改变收缩压和血脂水平，可能在墨西哥HT患者原发性高血压和血脂异常的发生发展中起重要作用。
