Pathy Sushmita, Chander Subhash
Department of Radiation Oncology, All India Institute Of Medical Sciences, Ansari Nagar, New Delhi - 110 029, India.
Indian J Med Paediatr Oncol. 2009 Apr;30(2):55-60. doi: 10.4103/0971-5851.60049.
Pancreatic cancer patients present late in their course and surgical resection as a modality of treatment is of limited value. Majority develop loco-regional failure and distant metastasis, therefore, adjuvant therapy comprising of radiotherapy and chemotherapy are useful treatment options to achieve higher loco-regional control. Specialized irradiation techniques like intra-operative radiotherapy that help to increase the total tumor dose have been used, however, controvertible survival benefit was observed. Various studies have shown improved median and overall survival with chemoradiotherapy for advanced unresectable pancreatic carcinoma. The role of new agents such as topoisomerase I inhibitors also needs further clinical investigations.
胰腺癌患者就诊时病情往往已处于晚期，手术切除作为一种治疗方式，其价值有限。大多数患者会出现局部区域复发和远处转移，因此，包括放疗和化疗的辅助治疗是实现更高局部区域控制的有效治疗选择。已采用如术中放疗等有助于增加肿瘤总剂量的特殊照射技术，然而，观察到的生存获益存在争议。多项研究表明，对于晚期不可切除的胰腺癌，放化疗可改善中位生存期和总生存期。拓扑异构酶I抑制剂等新型药物的作用也需要进一步的临床研究。
