Bora D K, Deb P
Nanoscale Res Lett. 2008 Nov 22;4(2):138-143. doi: 10.1007/s11671-008-9213-6.
A novel bioconjugate of stearic acid capped maghemite nanoparticle (gamma-Fe(2)O(3)) with bovine serum albumin (BSA) was developed by taking recourse to the fatty acid binding property of the protein. From FT-IR study, it was found that conjugation took place covalently between the amine group of protein molecule and carboxyl group of stearic acid capped maghemite nanoparticle. TEM study further signified the morphology of the proposed nanobioconjuagte. The binding constant of nanoparticle with protein molecule was evaluated from the optical property studies. Also, magnetic measurement (M-H) showed retaining of magnetic property by significant values of saturation magnetization and other hysteretic parameters.
利用蛋白质的脂肪酸结合特性，开发了一种新型的硬脂酸包覆磁赤铁矿纳米颗粒（γ-Fe(2)O(3)）与牛血清白蛋白（BSA）的生物共轭物。通过傅里叶变换红外光谱（FT-IR）研究发现，蛋白质分子的胺基与硬脂酸包覆磁赤铁矿纳米颗粒的羧基之间发生了共价结合。透射电子显微镜（TEM）研究进一步表明了所提出的纳米生物共轭物的形态。通过光学性质研究评估了纳米颗粒与蛋白质分子的结合常数。此外，磁性测量（M-H）表明，饱和磁化强度和其他磁滞参数的显著值表明其保留了磁性。
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