Tao Youhua, Liu Ren, Liu Xiaoya, Chen Mingqing, Yang Cheng, Ni Zhongbin
Nanoscale Res Lett. 2009 Jan 21;4(4):341-343. doi: 10.1007/s11671-009-9249-2.
pH-sensitive micelles with hydrophilic core and hydrophilic corona were fabricated by self-assembling of triblock copolymer of poly(methylacrylic acid)-poly(ethylene glycol)-poly(methylacrylic acid) at lower solution pH. Transmission electron microscopy and laser light scattering studies showed micelles were in nano-scale with narrow size distribution. Solution pH value and the micelles concentration strongly influenced the hydrodynamic radius of the spherical micelles (48-310 nm). A possible mechanism for the formation of micelles was proposed. The obtained polymeric micelle should be useful for biomedical materials such as carrier of hydrophilic drug.
通过聚（甲基丙烯酸）-聚（乙二醇）-聚（甲基丙烯酸）三嵌段共聚物在较低溶液pH值下自组装制备了具有亲水核和亲水冠的pH敏感胶束。透射电子显微镜和激光散射研究表明，胶束呈纳米级，粒径分布窄。溶液pH值和胶束浓度对球形胶束的流体力学半径（48 - 310 nm）有强烈影响。提出了胶束形成的一种可能机制。所获得的聚合物胶束可用于生物医学材料，如亲水药物载体。
