Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian Institute of Technology (ISM), Dhanbad 826004, India.
Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian Institute of Technology (ISM), Dhanbad 826004, India.
J Colloid Interface Sci. 2018 Aug 15;524:122-128. doi: 10.1016/j.jcis.2018.04.010. Epub 2018 Apr 3.
Polymeric micelles are fabricated by the self-aggregation of amphiphilic polymers in aqueous medium. Amphiphilic block copolymers consist of hydrophobic and hydrophilic blocks. The hydrophilic blocks form corona, while hydrophobic blocks produce core of the micelle.
In the present manuscript, a triblock copolymer derived from poly (ethylene glycol) and poly (vinyl acetate) (PVAc-b-PEG-b-PVAc) has been prepared via reversible addition-fragmentation chain transfer polymerization. Its structural properties as well as micellar stability have been studied and application as dye carrier has been discussed in details.
The GPC analysis shows the low polydispersity of the developed copolymer that signifies the controlled nature of polymerization. The copolymer demonstrates long-term micellar stability, which has been determined by dynamic light scattering (DLS) analysis. The block copolymer reveals excellent pH-triggered release behavior of loaded Nile red, which ascertained the dye carrier feature of PVAc-b-PEG-b-PVAc.
两亲聚合物在水介质中自组装形成聚合物胶束。两亲嵌段共聚物由疏水和亲水嵌段组成。亲水嵌段形成胶束的冠，而疏水嵌段则产生胶束的核。
在本手稿中，通过可逆加成-断裂链转移聚合制备了一种源自聚乙二醇和聚醋酸乙烯酯的三嵌段共聚物（PVAc-b-PEG-b-PVAc）。研究了其结构性能和胶束稳定性，并详细讨论了其作为染料载体的应用。
GPC 分析表明，所开发的共聚物具有低的多分散性，表明聚合具有可控性。通过动态光散射（DLS）分析表明，该共聚物具有长期的胶束稳定性。嵌段共聚物显示出尼罗红负载物的优异 pH 触发释放行为，证实了 PVAc-b-PEG-b-PVAc 的染料载体特性。
