Department of Dermatopathology, University Hospital Sart Tilman, B-4000 Liège, Belgium.
Int J Mol Med. 2010 Aug;26(2):171-4. doi: 10.3892/ijmm_00000449.
Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation and regeneration potential to the tissues in which they reside. This review focused on epidermal stem cells (ESCs). These cells are distinguished from transitory amplifier cells and post-mitotic cells. ESC are found in the interadnexal epidermis and in the bulge region of hair follicles. A series of ESCs markers are available, but increased sensitivity and specificity require further development.
皮肤包含体干细胞，这些干细胞可生成角蛋白细胞、黑素细胞和间充质细胞谱系。这些体干细胞的分化和再生潜能一直被认为仅限于其所在的组织。本综述重点介绍表皮干细胞 (ESC)。这些细胞与过渡性扩增细胞和有丝分裂后细胞不同。ESC 存在于附属器间表皮和毛囊的隆起区域。已经有一系列 ESC 标志物，但需要进一步开发以提高灵敏度和特异性。
