Liu Y, Liu X Y
Department of Burn, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2024 Mar 20;40(3):221-229. doi: 10.3760/cma.j.cn501225-20240108-00009.
Cell therapy includes living cell-based therapy and cell-derivative therapy that is based on extracellular vesicles and bioactive molecules. As a research hotspot in recent years, cell therapy is a potential strategy to solve the clinical problem of refractory wound repair. The rapid development of material science and cell biology has opened a new prelude to cell therapy, and at the same time, puts forward a new proposition on how to further optimize and apply cell therapy to wound repair. This article reviewed the cell types used for wound treatment, summarized the application and exploration of cell therapy-based new technologies, sorted out the difficulties in the clinical application of existing cell therapies, and looked into the future development trend of cell therapy for wound repair, in order to promote the development of innovative cell therapy system and further improve the clinical wound treatment effect.
细胞疗法包括基于活细胞的疗法以及基于细胞外囊泡和生物活性分子的细胞衍生疗法。作为近年来的研究热点,细胞疗法是解决难治性伤口修复临床问题的一种潜在策略。材料科学和细胞生物学的快速发展为细胞疗法开启了新篇章,同时也对如何进一步优化细胞疗法并将其应用于伤口修复提出了新的命题。本文综述了用于伤口治疗的细胞类型,总结了基于细胞疗法的新技术的应用与探索,梳理了现有细胞疗法临床应用中的难点,并展望了伤口修复细胞疗法的未来发展趋势,以推动创新性细胞疗法体系的发展,进一步提高临床伤口治疗效果。