Schellong S M
Medizinische Klinik, Krankenhaus Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
Internist (Berl). 2010 Aug;51(8):995-8, 1000-2. doi: 10.1007/s00108-009-2541-5.
Acute pulmonary embolism requires ICU management only for patients with hemodynamic instability who need artificial ventilation, or for hemodynamically stable patients with significant right ventricular dysfunction. For both patient groups, echocardiography is the most relevant diagnostic method. The main therapeutic consideration is on systemic thrombolysis. It is indicated in almost all patients with hemodynamic instability but only in selected cases of right ventricular dysfunction. All other patients receive standard anticoagulation only. A second vascular emergency scenario is type 2 heparin-induced thrombocytopeniae (HIT II) which may cause venous as well as arterial complications. Alternative anticoagulation has to be established from the first moment of clinical suspicion. It has to be continued in a therapeutic dosage if HIT II is confirmed, and has to be stopped if the diagnosis is refuted. The latter case is by far more frequent. Regarding arterial occlusions (acute limb ischemia, acral gangrene, iatrogenic vascular trauma) hints are given for the management in the setting of intensive care.
急性肺栓塞仅需要对血流动力学不稳定且需要人工通气的患者,或对血流动力学稳定但有明显右心室功能障碍的患者进行重症监护病房管理。对于这两类患者,超声心动图是最相关的诊断方法。主要的治疗考虑是全身溶栓。几乎所有血流动力学不稳定的患者都适用,但仅在右心室功能障碍的特定病例中适用。所有其他患者仅接受标准抗凝治疗。第二种血管急症情况是2型肝素诱导的血小板减少症(HIT II),它可能导致静脉和动脉并发症。从临床怀疑的第一刻起就必须建立替代抗凝治疗。如果确诊为HIT II,必须以治疗剂量持续使用,如果诊断被否定则必须停止。后一种情况更为常见。关于动脉闭塞(急性肢体缺血、肢端坏疽、医源性血管创伤),文中给出了重症监护环境下的管理提示。