嗅神经母细胞瘤。
Olfactory neuroblastoma.
作者信息
Thompson Lester D R
机构信息
Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, 5601 De Soto Avenue, Woodland Hills, CA 91365, USA.
出版信息
Head Neck Pathol. 2009 Sep;3(3):252-9. doi: 10.1007/s12105-009-0125-2. Epub 2009 Jul 16.
Few neoplasms are unique to the sinonasal tract, but sinonasal undifferentiated carcinoma and olfactory neuroblastoma are malignant tumors which require unique management. Due to the rarity of these tumors, practicing pathologists are not always aware of their distinctive clinical, radiographic, histologic, immunohistochemical, and molecular features. These cases are frequently submitted for consultation, further suggesting the diagnostic difficulties inherent to these tumors. Specifically, olfactory neuroblastoma is a neoplasm that can histologically mimic many tumors within the sinonasal tract, making recognition of this tumor important, as the management frequently requires a bicranial-facial surgical approach, a trephination procedure which can be quite technically difficult and challenging to achieve a good result. The management is therefore quite unique in comparison to other sinonasal tract malignancies, setting it apart diagnostically and managerially from other lesions.
很少有肿瘤是鼻窦道所特有的，但鼻窦未分化癌和嗅神经母细胞瘤是需要独特治疗的恶性肿瘤。由于这些肿瘤罕见，执业病理学家并不总是了解其独特的临床、影像学、组织学、免疫组化和分子特征。这些病例经常提交进行会诊，这进一步表明了这些肿瘤固有的诊断困难。具体而言，嗅神经母细胞瘤是一种在组织学上可模仿鼻窦道内许多肿瘤的肿瘤，因此识别这种肿瘤很重要，因为其治疗通常需要采用双颅面手术方法，这是一种钻孔手术，在技术上可能相当困难且具有挑战性，难以取得良好效果。因此，与其他鼻窦道恶性肿瘤相比，其治疗相当独特，在诊断和管理上与其他病变有所不同。
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