Palmieri Daniel E, Tadokoro Kent S, Valappil Benita, Pakala Theja, Muthukrishnan Ashok, Seethala Raja R, Snyderman Carl H
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
J Neurol Surg B Skull Base. 2023 Jun 12;85(5):439-444. doi: 10.1055/a-2096-1802. eCollection 2024 Oct.
Olfactory neuroblastoma (ONB), or esthesioneuroblastoma, is a rare neuroectodermal tumor of the nasal cavity and paranasal sinuses. Most of these tumors express somatostatin receptors (SSTRs), providing a potential target for radionuclide imaging with Ga-68 DOTATATE. However, this imaging modality has not been extensively studied in ONB. We conducted a retrospective chart review of 96 endoscopic endonasal skull base surgery cases for ONB performed at our institution between 2000 and 2021. Histo (H) scores were assigned to each tumor and normalized DOTATATE standardized uptake values (nSUVs) were measured as well. Nine patients (5 males and 4 females) with ONB were ultimately included in the study. The average age of the patients was 50 years. All ONBs had a positive SSTR2 expression (H-score > 105; mean: 180). All ONBs showed DOTATATE avidity (mean nSUV for ONB: 6.7). However, there was no correlation between H-score and nSUV, with an of 0.24 ( = 0.18). Our study shows that SSTR2 expression is found in all ONBs with associated DOTATATE avidity, which may serve as a valuable imaging modality to monitor for recurrent and metastatic disease in ONB.
嗅神经母细胞瘤（ONB），又称感觉神经母细胞瘤，是鼻腔和鼻窦罕见的神经外胚层肿瘤。这些肿瘤大多表达生长抑素受体（SSTRs），为用镓-68 DOTATATE进行放射性核素成像提供了潜在靶点。然而，这种成像方式在ONB中尚未得到广泛研究。
我们对2000年至2021年期间在本机构进行的96例ONB内镜鼻内颅底手术病例进行了回顾性病历审查。为每个肿瘤分配组织学（H）评分，并测量标准化的DOTATATE标准化摄取值（nSUVs）。
最终，9例ONB患者（5例男性和4例女性）被纳入研究。患者的平均年龄为50岁。所有ONB均有SSTR2阳性表达（H评分>105；平均：180）。所有ONB均显示对DOTATATE有摄取（ONB的平均nSUV：6.7）。然而，H评分与nSUV之间无相关性，相关系数为0.24（P=0.18）。
我们的研究表明，所有ONB均有SSTR2表达并伴有对DOTATATE的摄取，这可能是监测ONB复发和转移疾病的一种有价值的成像方式。
