Kojima Masaru, Shimizu Ken, Shimizu Kazuhiko, Masawa Nobuhide
Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, 617-1, Takabayashinishi-cho, Ohta, 373-8550, Japan.
Head Neck Pathol. 2009 Mar;3(1):27-30. doi: 10.1007/s12105-008-0087-9. Epub 2008 Sep 24.
We present here two cases of incidental extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) showing prominent plasma cell differentiation associated with Hashimoto's thyroiditis (HT). Histological examination demonstrated that both lesions exhibited HT including lymphoplasmacytic infiltration with the formation of germinal centers, destruction of the normal thyroid follicular architecture, Hürthle cell changes, and squamous metaplasia. The dominant tumor nodules of both cases contained large, well-circumscribed but unencapsulated aggregation of mature plasma cells and scattered centrocyte-like cells (CCL-cells). Both lesions contained a few lymphoepithelial lesions. Moreover, immunohistochemical study demonstrated that plasma cells and CCL-cells of these two lesions contained monotypic intracytoplasmic kappa light chain. Other small B-cell lymphomas, plasmacytoma and plasmablastic lymphoma were excluded using stains for CD5, CD10, CD23, CD43, CD56. Cyclin D1, human herpes virus type-8.
我们在此呈现两例黏膜相关淋巴组织边缘区B细胞淋巴瘤（MALT淋巴瘤），其表现为与桥本甲状腺炎（HT）相关的显著浆细胞分化。组织学检查显示，两个病变均表现为HT，包括伴有生发中心形成的淋巴浆细胞浸润、正常甲状腺滤泡结构破坏、许特莱细胞改变和鳞状化生。两例病例的主要肿瘤结节均包含大量成熟浆细胞的大的、边界清楚但无包膜的聚集物以及散在的中心细胞样细胞（CCL细胞）。两个病变均含有一些淋巴上皮病变。此外，免疫组化研究表明，这两个病变的浆细胞和CCL细胞含有单型胞浆内κ轻链。使用CD5、CD10、CD23、CD43、CD56、细胞周期蛋白D1、人疱疹病毒8型染色排除了其他小B细胞淋巴瘤、浆细胞瘤和浆母细胞淋巴瘤。
