Deniz Kemal, Patiroğlu Tahir E, Okten Turhan
Department of Pathology, Faculty of Medicine, Erciyes University, Turkey.
APMIS. 2008 Feb;116(2):167-72. doi: 10.1111/j.1600-0463.2008.00827.x.
We report two cases of thyroidal plasma cell granuloma. Both patients underwent surgical resection after presenting with painless neck swelling. Histopathologic examination of the specimens revealed plasmacytes infiltrating the thyroid parenchyma and immunohistochemical studies showed the polyclonal nature of the plasma cells. Plasma cell granuloma is a benign lesion and its appearance in the thyroid gland is extremely rare. Eleven prior cases with thyroid localization have been reported to date in the English literature. Nine of the plasma cell granuloma cases occurred in women, four in men (including the present cases). The clinicopathologic features and diagnostic difficulties of this rare entity are described, and its relation to inflammatory pseudotumor of other sites is discussed with a review of the literature.
我们报告两例甲状腺浆细胞性肉芽肿。两名患者均在出现无痛性颈部肿胀后接受了手术切除。标本的组织病理学检查显示浆细胞浸润甲状腺实质，免疫组织化学研究显示浆细胞的多克隆性质。浆细胞性肉芽肿是一种良性病变，其在甲状腺中的出现极为罕见。迄今为止，英文文献中已报道了11例先前甲状腺定位的病例。其中9例浆细胞性肉芽肿病例发生在女性，4例发生在男性（包括本病例）。描述了这种罕见实体的临床病理特征和诊断难点，并结合文献复习讨论了其与其他部位炎性假瘤的关系。
