Kriegl Lydia, Guetgemann Ines, Zhou Hui
Institute of Pathology, Ludwig-Maximilians-University of Munich, Germany.
Pathol Res Pract. 2007;203(11):813-7. doi: 10.1016/j.prp.2007.07.005. Epub 2007 Sep 5.
Plasma cell granulomas (PCG) are rare tumor-like lesions consisting of sheets of polyclonal plasma cells admixed with numerous lymphocytes and other inflammatory cells surrounded by fibrous stroma. They usually appear in the lung, but involvement of diverse extrapulmonal sites has been described. PCGs occurring in the thyroid are very uncommon. Since 1981, only 11 cases have been described in the English literature. Here, we present the case of a 50-year-old Arabic man who noticed an enlargement of his thyroid gland during the previous 2 years, and he developed swallowing disturbances and a feeling of narrowness in the neck. A nearly total resection of the thyroid gland was made because of clinical suspicion of carcinoma. On histologic examination, PCG of the thyroid associated with Hashimoto's thyroiditis (HT) was diagnosed. This is the first case in which molecular pathological analyses for EBV and HHV8 DNA were made. As these were negative, distinct etiological features were suggested.
浆细胞性肉芽肿（PCG）是一种罕见的肿瘤样病变，由多克隆浆细胞片层组成，混有大量淋巴细胞和其他炎症细胞，周围有纤维性间质。它们通常出现在肺部，但也有累及各种肺外部位的报道。发生在甲状腺的PCG非常罕见。自1981年以来，英文文献中仅描述了11例。在此，我们报告一例50岁的阿拉伯男性病例，该患者在过去2年中发现甲状腺肿大，并出现吞咽障碍和颈部狭窄感。由于临床怀疑为癌，对甲状腺进行了近全切除。组织学检查诊断为与桥本甲状腺炎（HT）相关的甲状腺PCG。这是首例对EBV和HHV8 DNA进行分子病理分析的病例。由于结果为阴性，提示了独特的病因特征。
