Koćmierska-Grodzka D
Strahlentherapie. 1978 Apr;154(4):282-6.
The role of some agonists of the adrenergic system and inhibitors of phosphodiesterase activity in the modulation of the degree of lipase release from pancreatic granular fraction (zymogen and lysosomes) of control and X-ray irradiated rats was investigated. It was shown the decrease of the release of enzymatic activity under the influence of cyclic adenosine monophosphate (cAMP) and noradrenaline (NA) in the fractions from both investigated groups. Effects were dependent on the concentration used. Isoprenaline evoked opposite changes in control and irradiated specimens. In controls it facilitated the enzyme release when applied in smaller (10(-8)M) concentration. In granules from irradiated animals the decrease of enzyme release was noted under the influence of greater concentration (10(-6)M) of the drug. The action of papaverine was nearly similar in control and irradiated groups. The drug evoked the decrease or increase of enzyme release when applied in greater (10(-6)M) or smaller (10(-8)M) concentration respectively. Lipase release was markedly enhanced in controls by theophylline (both concentrations); in specimens from irradiated pancreas, however, no significant alterations were observed.
研究了肾上腺素能系统的一些激动剂和磷酸二酯酶活性抑制剂对正常和X射线照射大鼠胰腺颗粒组分（酶原和溶酶体）脂肪酶释放程度的调节作用。结果表明，在环磷酸腺苷（cAMP）和去甲肾上腺素（NA）的影响下，两个研究组的组分中酶活性释放均降低。其作用效果取决于所用浓度。异丙肾上腺素在正常和照射标本中引起相反的变化。在正常标本中，以较低浓度（10^(-8)M）应用时促进酶释放。在照射动物的颗粒中，较高浓度（10^(-6)M）的该药物会导致酶释放减少。罂粟碱在正常和照射组中的作用几乎相似。该药物分别以较高浓度（10^(-6)M）或较低浓度（10^(-8)M）应用时，会引起酶释放减少或增加。茶碱（两种浓度）在正常标本中显著增强脂肪酶释放；然而，在照射胰腺的标本中未观察到明显变化。
