某些辐射防护剂对胰腺亚细胞组分辐射后水解功能影响的比较研究。
Comparative studies on the influence of some radioprotectors on the postirradiation hydrolytic function of subcellular fractions of pancreas.
作者信息
Koćmierska-Grodzka D
出版信息
Strahlentherapie. 1977 Dec;153(12):837-42.
Comparative studies on the influence of the two radioprotectors Fenchlorfos and cysteamine on the hydroproteolytic activity of pancreatic subcellular fractions of rats were carried out. The animals were irradiated with the single dose of 800 R of X-rays. Biochemical estimation of lipase, beta-glucuronidase, acid phosphatase and catheptic (caseinolytic) activity were done 24 hours after exposition. The two radioprotective substances have a lot of common in their action against hydrolytic activity. They induce the decrease of some enzymes of subcellular fractions we checked both in control as well as in irradiated groups. The ambivalent influence of Trichlorfon on the lipase activity in granules and supernatant fraction seems to be of interest.
开展了比较研究，以探讨两种辐射防护剂倍硫磷和半胱胺对大鼠胰腺亚细胞组分水解活性的影响。动物接受单次800伦琴的X射线照射。照射后24小时进行了脂肪酶、β-葡萄糖醛酸酶、酸性磷酸酶和组织蛋白酶（酪蛋白分解）活性的生化测定。这两种辐射防护物质在对抗水解活性的作用方面有许多共同之处。它们在对照组和照射组中均诱导了我们检测的亚细胞组分中某些酶活性的降低。敌百虫对颗粒和上清液组分中脂肪酶活性的矛盾影响似乎值得关注。
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