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儿童过敏性鼻炎

Allergic rhinitis in children.

作者信息

Turner Paul J, Kemp Andrew S

机构信息

Department of Allergy and Immunology, The Children's Hospital at Westmead, New South Wales, Australia.

出版信息

J Paediatr Child Health. 2012 Apr;48(4):302-10. doi: 10.1111/j.1440-1754.2010.01779.x. Epub 2010 Jun 27.

Abstract

Allergic rhinitis affects up to 40% of children but is commonly undiagnosed. Careful assessment of nasal symptoms allows for the most appropriate therapeutic options to be chosen. Allergen avoidance is often difficult in practice. Antihistamines are of limited benefit in allergic rhinitis caused by house dust mite and other perennial allergens, where symptoms, predominantly nasal obstruction, are not histamine mediated. In contrast, symptoms triggered by pollen, such as nasal itch, rhinorrhoea and sneezing, are relieved by antihistamines. Intranasal steroids are the treatment of choice for persistent moderate-severe allergic rhinitis and are more effective than antihistamines for relief of nasal obstruction. Failure to respond to intranasal medications is often caused by poor compliance or inefficient use of nasal sprays. Immunotherapy may be a useful, if expensive, option, particularly where symptoms are because of a specific pollen. The benefits of immunotherapy in house dust mite-induced rhinitis and asthma remain controversial.

摘要

变应性鼻炎影响多达40%的儿童,但通常未被诊断出来。仔细评估鼻部症状有助于选择最合适的治疗方案。在实际操作中,避免接触过敏原往往很困难。抗组胺药对由屋尘螨和其他常年性过敏原引起的变应性鼻炎益处有限,在这些鼻炎中,症状(主要是鼻塞)并非由组胺介导。相比之下,花粉引发的症状,如鼻痒、流涕和打喷嚏,可通过抗组胺药缓解。鼻用类固醇是持续性中重度变应性鼻炎的首选治疗方法,在缓解鼻塞方面比抗组胺药更有效。对鼻用药物无反应通常是由于依从性差或鼻喷雾剂使用不当所致。免疫疗法可能是一种有用的选择,尽管费用较高,特别是在症状由特定花粉引起的情况下。免疫疗法对屋尘螨诱发的鼻炎和哮喘的益处仍存在争议。

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