Bosman S, Phoa S S, Bosma A, van Gemert M J
Laser Centre, University of Amsterdam, The Netherlands.
Br J Surg. 1991 May;78(5):572-5. doi: 10.1002/bjs.1800780517.
Tumour necrosis can be induced by interstitial application of low power laser light, which causes thermal damage to the tissue. In normal pig liver the effects were studied of low power Nd:YAG laser light (continuous wave; 1.5 W, 10 min, wavelength 1064 nm), administered percutaneously via a 600 micron fibre. Ultrasound images were compared with histopathological findings. Histopathology showed induction of sharply demarcated lesions with a mean diameter of 10-15 mm (days 0 and 7), consisting of coagulative necrosis. Healing of the lesion occurred by granulation, fibrosis and removal of cell debris. Lesions could not be seen by week 4, which suggests complete regeneration. Ultrasonography showed a good correlation with histopathology, especially at 1 week when different histopathological tissue layers could be discriminated by ultrasonography. It is concluded that thermal lesions in liver can be induced via a percutaneous route and that ultrasound imaging is useful in monitoring the lesions during and after the procedure.
间质内应用低功率激光可诱导肿瘤坏死，这会对组织造成热损伤。在正常猪肝中，研究了通过一根600微米的光纤经皮给予低功率钕:钇铝石榴石激光（连续波；1.5瓦，10分钟，波长1064纳米）的效果。将超声图像与组织病理学结果进行了比较。组织病理学显示诱导出界限清晰的病变，平均直径为10 - 15毫米（第0天和第7天），由凝固性坏死组成。病变通过肉芽组织形成、纤维化和细胞碎片清除而愈合。到第4周时病变已不可见，这表明完全再生。超声检查与组织病理学显示出良好的相关性，尤其是在第1周时，不同的组织病理学组织层可通过超声检查进行区分。结论是肝内的热损伤可通过经皮途径诱导产生，并且超声成像在监测手术过程中和手术后的病变方面是有用的。
