Steger A C, Lees W R, Shorvon P, Walmsley K, Bown S G
National Medical Laser Centre, University College and Middlesex Hospital Medical School, London, UK.
Br J Surg. 1992 Feb;79(2):139-45. doi: 10.1002/bjs.1800790215.
Multiple four-fibre low-power interstitial laser hyperthermia was performed in the canine liver to establish the parameters with which large areas of thermal necrosis could be made. Using 1.5 W for 670 s (4020 J in total) and a fibre spacing of 1.5 cm, lesions with dimensions of 3.6 x 3.1 x 2.8 cm were achieved in 75 per cent of those attempted. There was no mortality and a low morbidity rate. These lesions could be visualized in both their development and resolution using ultrasonography. Healing occurred by 1 year. Temperatures in the centre of the heated region were 60 degrees C, which is more than enough to cause thermal cell death. There was good correlation between the temperatures recorded, the sonographic changes seen, and the pathological evidence of necrosis. Multiple-fibre low-power interstitial laser hyperthermia performed with ultrasonic guidance may be of use in the treatment of liver tumours.
在犬肝脏中进行了多次四光纤低功率间质激光热疗，以确定能够造成大面积热坏死的参数。使用1.5瓦功率持续670秒（总计4020焦耳），光纤间距为1.5厘米，在75%的尝试中实现了尺寸为3.6×3.1×2.8厘米的病灶。无死亡病例，发病率低。使用超声检查可以观察到这些病灶的发展和消退过程。1年内实现愈合。加热区域中心的温度为60摄氏度，足以导致细胞热死亡。记录的温度、观察到的超声变化与坏死的病理证据之间存在良好的相关性。在超声引导下进行的多光纤低功率间质激光热疗可能用于治疗肝脏肿瘤。
