Hakanen Maarit, Raitakari Olli T, Lehtimäki Terho, Peltonen Nina, Pahkala Katja, Sillanmäki Lauri, Lagström Hanna, Viikari Jorma, Simell Olli, Rönnemaa Tapani
The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
J Clin Endocrinol Metab. 2009 Apr;94(4):1281-7. doi: 10.1210/jc.2008-1199. Epub 2009 Jan 21.
A common variant in the FTO gene, rs9939609, associates with body mass index (BMI) in adults and in children aged 7 yr or older.
Our aim was to examine the associations of the FTO genotype with BMI, cardiovascular risk factors, energy intake, and leisure-time physical activity in children followed up since infancy.
Healthy participants of the STRIP Study, genotyped for rs9939609, were followed from age 7 months (n = 640) to 15 yr (n = 438). The children were randomly assigned to lifestyle intervention and control groups. Height, weight, blood pressure, and serum lipids were measured annually. Food records and physical activity index were obtained at age 15 yr.
The FTO genotype did not associate with BMI in children younger than 7 yr of age. From age 7 yr onward, the children homozygous for the A allele had progressively higher BMI than the children with one or two T alleles (P = 0.029 for FTO by age interaction). Furthermore, in longitudinal, BMI Z-score-adjusted analysis, the AA genotype associated with higher systolic and diastolic blood pressure and with elevated serum total and low-density lipoprotein-cholesterol (P = 0.01, P < 0.001, P = 0.05, and P = 0.04 for main effect, respectively). The FTO genotype did not associate with energy intake or physical activity index at age 15. The FTO *Study group interactions were not significant.
Our results suggest that the effect of the FTO genotype on BMI becomes evident only after age 7 yr. These results further suggest that the FTO gene is not directly associated with energy intake or physical activity.
FTO基因中的常见变体rs9939609与成年人以及7岁及以上儿童的体重指数（BMI）相关。
我们的目的是研究自婴儿期起接受随访的儿童中FTO基因型与BMI、心血管危险因素、能量摄入和休闲时间身体活动之间的关联。
对STRIP研究中的健康参与者进行rs9939609基因分型，从7个月大（n = 640）随访至15岁（n = 438）。这些儿童被随机分配到生活方式干预组和对照组。每年测量身高、体重、血压和血脂。在15岁时获取食物记录和身体活动指数。
FTO基因型与7岁以下儿童的BMI无关。从7岁起，A等位基因纯合的儿童的BMI逐渐高于具有一个或两个T等位基因的儿童（FTO基因与年龄的交互作用P = 0.029）。此外，在纵向的、经BMI Z评分调整的分析中，AA基因型与较高的收缩压和舒张压以及血清总胆固醇和低密度脂蛋白胆固醇升高相关（主效应分别为P = 0.01、P < 0.001、P = 0.05和P = 0.04）。FTO基因型与15岁时的能量摄入或身体活动指数无关。FTO基因与研究组的交互作用不显著。
我们的结果表明，FTO基因型对BMI的影响仅在7岁以后才变得明显。这些结果进一步表明，FTO基因与能量摄入或身体活动没有直接关联。
