Departments of Pathology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Gastrointest Endosc. 2010 Jun;71(7):1130-3. doi: 10.1016/j.gie.2010.01.051.
EUS is a standard staging procedure in esophageal cancer. For adequate staging, FNA of suspicious lymph nodes is recommended. Based on optimal staging, sophisticated treatment can be applied more properly. The working channel of the endoscope can potentially be contaminated by cancer cells derived from the luminal surface of esophageal cancer during EUS-guided FNA, which may result in false-positive cytology results of EUS-guided FNA of celiac lymph nodes.
To determine whether passing an endoscope through intraluminal esophageal cancer can lead to contamination of the working channel with tumor cells.
An ex vivo assessment of contamination of endoscope working channels.
University hospital.
This study involved 13 patients with esophageal cancer.
Working channels of endoscopes that had been used in patients with intraluminal esophageal cancer were studied immediately after EUS. A routine ex vivo FNA was performed through the endoscope on 8 patients. The same procedure was performed through the endoscope on 5 other patients after the working channel had been cleaned by extensive flushing.
Semiquantitative scoring of cytology smears.
Six of 8 specimens contained carcinoma cells. No contamination by carcinoma cells or normal cells was observed when the working channel was flushed with tap water prior to the sham FNA procedure.
This was an ex vivo study of a limited group of patients.
The working channel of the endoscope can be contaminated during the EUS-guided FNA procedure. Cancer cell contamination can be avoided by flushing the endoscope.
EUS 是食管癌的标准分期程序。为了进行充分的分期，建议对可疑淋巴结进行 FNA。基于最佳分期，可以更适当地应用复杂的治疗。在 EUS 引导的 FNA 过程中，来自食管癌管腔表面的癌细胞可能会污染内镜的工作通道，这可能导致 EUS 引导的腹腔淋巴结 FNA 的细胞学结果出现假阳性。
确定在 EUS 引导的 FNA 过程中，通过内镜穿过腔内食管癌是否会导致工作通道被肿瘤细胞污染。
对内镜工作通道污染的体外评估。
大学医院。
这项研究涉及 13 名食管癌患者。
研究了在腔内食管癌患者中使用过的内镜的工作通道。对 8 名患者通过内镜进行了常规的体外 FNA。对 5 名其他患者，在工作通道经过大量冲洗清洁后，通过内镜进行相同的操作。
细胞学涂片的半定量评分。
8 个标本中有 6 个含有癌细胞。在 sham FNA 程序之前，用自来水冲洗工作通道时，未观察到癌细胞或正常细胞的污染。
这是一项对有限数量患者进行的体外研究。
在 EUS 引导的 FNA 过程中，内镜的工作通道可能会被污染。通过冲洗内镜可以避免癌细胞污染。
