Ghent University, Faculty of Veterinary Medicine, Department of Morphology, Merelbeke, Belgium.
Acta Histochem. 2011 Sep;113(5):585-90. doi: 10.1016/j.acthis.2010.05.001. Epub 2010 Jul 3.
Angiopoietins are growth factors involved in vascular development. They also play an important role in the development of the kidney vasculature. The localization of these growth factors was immunohistochemically investigated in developing porcine metanephric kidneys. Angiopoietin 1 was predominantly present in the maturing glomeruli, while angiopoietin 2 was observed in the early developing glomeruli as well as in maturing glomeruli. Furthermore, angiopoietin 2 was observed in the muscle layer of renal arteries, in the convoluted tubules and in the loops of Henle. In contrast to the situation in the mouse in which angiopoietin 2 has been reported to be mainly expressed in mesangial cells near the glomerular hilus, expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus. The results of this study support the hypothesis that the angiopoietins play an important role during mammalian metanephric development and during glomerulogenesis in particular, but indicate that species specific characteristics must be taken into account when evaluating their involvement in glomerulogenesis.
血管生成素是参与血管发育的生长因子。它们在肾脏血管发育中也起着重要作用。本研究通过免疫组织化学方法研究了这些生长因子在发育中的猪后肾中的定位。血管生成素 1 主要存在于成熟的肾小球中，而血管生成素 2 则存在于早期发育的肾小球和成熟的肾小球中。此外，血管生成素 2 还存在于肾动脉的肌层、曲小管和亨利氏袢中。与在小鼠中血管生成素 2 主要在肾小球门附近的系膜细胞中表达的情况不同，在猪后肾中观察到血管生成素 2 存在于早期发育的肾小球中的足细胞中，但不存在于肾小球门附近的细胞中。本研究的结果支持了这样的假设，即血管生成素在哺乳动物后肾发育和肾小球发生过程中起着重要作用，但表明在评估它们在肾小球发生中的作用时，必须考虑物种特异性特征。
