Department of Microbiology, Monash University, Victoria, Australia.
Trends Parasitol. 2010 Dec;26(12):591-9. doi: 10.1016/j.pt.2010.06.012. Epub 2010 Jul 2.
Over the past decade or so, our understanding of the biology of apicomplexan parasites has increased dramatically, particularly in the case of malaria. Notable achievements are the availability of complete genome sequences, transcriptome and proteome profiles and the establishment of in vitro transfection techniques for asexual-stage malaria parasites. Interestingly, despite their major economic importance and striking similarities with malaria, Babesia parasites have been relatively ignored, but change is on the horizon. Here, we bring together recent work on Babesia bovis parasites which are beginning to unravel the molecular mechanisms that underlie the pathogenesis of babesiosis and highlight some opportunities and challenges that lie ahead.
在过去的十年左右时间里，我们对顶复门寄生虫生物学的理解有了显著提高，特别是在疟疾方面。显著的成就是获得了完整的基因组序列、转录组和蛋白质组图谱，并建立了无性阶段疟原虫的体外转染技术。有趣的是，尽管巴贝斯虫类寄生虫具有重要的经济意义，并且与疟疾具有惊人的相似性，但它们一直被相对忽视，但这种情况即将改变。在这里，我们汇集了最近关于牛巴贝斯虫的研究工作，这些工作开始揭示导致巴贝斯虫病发病机制的分子机制，并强调了未来的一些机遇和挑战。
