Brockman R P
Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada.
Can J Physiol Pharmacol. 1991 Apr;69(4):475-9. doi: 10.1139/y91-071.
Epinephrine caused hyperglycemia in part by increasing gluconeogenesis. However, the mechanism of its gluconeogenic effects has not been studied in ruminants. This study was undertaken to examine the effect of epinephrine on the net hepatic uptake of selected glucose precursors in sheep. The major abdominal blood vessels of the sheep were catheterized in normal and alloxan diabetic sheep. Glucose production, metabolic clearance of glucose, and the hepatic removal of certain glucose precursors were determined before, during, and after epinephrine infusion. Epinephrine increased the hepatic glucose output, the concentrations of lactate and glycerol in plasma, and the net hepatic uptake and fractional hepatic extraction of lactate and glycerol. These effects were independent of changes in the concentrations of insulin and glucagon in plasma. These results show that epinephrine directly stimulates hepatic gluconeogenesis in sheep.
肾上腺素部分通过增加糖异生作用导致血糖升高。然而，其糖异生作用的机制在反刍动物中尚未得到研究。本研究旨在探讨肾上腺素对绵羊肝脏对选定葡萄糖前体的净摄取的影响。在正常和四氧嘧啶糖尿病绵羊中，将其主要腹部血管进行插管。在输注肾上腺素之前、期间和之后，测定葡萄糖生成、葡萄糖的代谢清除率以及肝脏对某些葡萄糖前体的清除情况。肾上腺素增加了肝脏葡萄糖输出、血浆中乳酸和甘油的浓度，以及肝脏对乳酸和甘油的净摄取和肝脏分数提取率。这些作用与血浆中胰岛素和胰高血糖素浓度的变化无关。这些结果表明，肾上腺素直接刺激绵羊肝脏的糖异生作用。
