Brockman R P
Can J Physiol Pharmacol. 1985 Nov;63(11):1460-4. doi: 10.1139/y85-239.
Ruminant animals, as a result of the fermentative nature of their digestion, ordinarily absorb little or no hexose sugar from the gut. Their glucose needs must be met by gluconeogenesis, even postprandially. The role of insulin in regulating hepatic gluconeogenesis in ruminants has not been assessed. In this study the effect of insulin on net hepatic removal of the major glucose precursors was determined. Insulin was infused with glucose matched to maintain euglycemia. The insulin concentrations attained in plasma were within the physiological range. Insulin at low concentrations reduced the hepatic removal of lactate, glutamine, and glycerol. At higher concentrations of insulin the hepatic extractions of pyruvate and alanine were also reduced. Thus, in sheep insulin at physiological concentrations may reduce hepatic glucose output by altering the uptake of glucose precursors.
反刍动物由于其消化的发酵特性，通常从肠道吸收很少或不吸收己糖。即使在餐后，它们的葡萄糖需求也必须通过糖异生来满足。胰岛素在调节反刍动物肝脏糖异生中的作用尚未得到评估。在本研究中，测定了胰岛素对肝脏主要葡萄糖前体净清除率的影响。胰岛素与葡萄糖一起输注以维持血糖正常。血浆中达到的胰岛素浓度在生理范围内。低浓度胰岛素降低了肝脏对乳酸、谷氨酰胺和甘油的清除率。在较高胰岛素浓度下，肝脏对丙酮酸和丙氨酸的摄取也降低。因此，在绵羊中，生理浓度的胰岛素可能通过改变葡萄糖前体的摄取来降低肝脏葡萄糖输出。
