Department of Psychiatry, University Medical Center Groningen, P.O. Box 660, 9700 AR, Groningen, The Netherlands.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 1;34(8):1390-5. doi: 10.1016/j.pnpbp.2010.06.028. Epub 2010 Jul 3.
Dysregulation of the immune system may play a role in tic disorders. We screened for immune disturbances by investigating serum levels of cytokines and soluble adhesion molecules in patients with a tic disorder.
Serum levels of interleukin (IL)-2, IL-4, IL-5, IL-10, IL-12, soluble IL-2 receptor (sIL2R), tumor necrosis factor (TNF)-α, interferon (IFN)-γ, soluble vascular cell adhesion molecule-1 (sVCAM-1), and intercellular adhesion molecule-1 (sICAM-1) of 66 children and adolescents with a tic disorder and 71 healthy volunteers were compared. We also addressed possible relations between concentrations of the immune markers and severity of tics and comorbid obsessive-compulsive symptoms.
Median serum concentrations did not differ significantly between patients and healthy subjects. Serum IL-2 concentrations were positively associated with tic severity ratings; serum IL-12 concentrations negatively with severity ratings of obsessive-compulsive symptoms.
These preliminary findings do not reveal major immune activation in children with a tic disorder but may suggest more subtle disturbances related to disease expression.
免疫系统失调可能在抽动障碍中起作用。我们通过检测细胞因子和可溶性黏附分子在抽动障碍患者血清中的水平来筛查免疫紊乱。
我们比较了 66 名抽动障碍患儿和 71 名健康志愿者的血清白细胞介素（IL）-2、IL-4、IL-5、IL-10、IL-12、可溶性白细胞介素-2 受体（sIL2R）、肿瘤坏死因子（TNF）-α、干扰素（IFN）-γ、可溶性血管细胞黏附分子-1（sVCAM-1）和细胞间黏附分子-1（sICAM-1）的浓度。我们还探讨了免疫标志物的浓度与抽动严重程度和共患强迫症症状之间的可能关系。
患者和健康受试者的血清浓度中位数无显著差异。血清 IL-2 浓度与抽动严重程度评分呈正相关；血清 IL-12 浓度与强迫症症状严重程度评分呈负相关。
这些初步发现并未显示出抽动障碍儿童存在主要的免疫激活，但可能提示与疾病表现相关的更微妙的紊乱。
