大鼠蔗糖觅药行为的恢复：D2 多巴胺受体的作用。
Renewal of sucrose-seeking behavior in rats: Role of D(2) dopamine receptors.
机构信息
Department of Psychology, James Hall, Dickinson College, Carlisle, PA 17013, USA.
出版信息
Pharmacol Biochem Behav. 2010 Sep;96(3):354-62. doi: 10.1016/j.pbb.2010.06.006. Epub 2010 Jun 17.
The present study characterized renewal of sucrose-seeking behavior in rats (Experiment 1). The role of the dopamine subtype-2 (D(2)) receptors in mediating renewal of sucrose-seeking behavior also was examined (Experiment 2). Rats were trained to respond for sucrose pellets (45mg each) on a fixed-ratio 25 (Experiments 1 and 2) schedule of reinforcement in Context A. Following acquisition, rats underwent extinction and 4 renewal tests in Contexts B and A, respectively. In Experiment 2, rats were pretreated with vehicle or the D(2) dopamine receptor antagonist eticlopride (5, 10, 20, or 40microg/kg) 30min prior to the first renewal test session. A follow-up experiment (Experiment 3) examined the effect of a high eticlopride dose (40microg/kg) on locomotor activity. Renewal of sucrose-seeking behavior persisted for 3 sessions. Eticlopride dose-dependently blocked renewal of sucrose-seeking behavior without suppressing locomotor activity, implicating a role of D(2) dopamine receptors in mediating renewal of sucrose-seeking behavior.
本研究描述了大鼠中蔗糖寻求行为的更新（实验 1）。还研究了多巴胺 D2 受体亚型在介导蔗糖寻求行为更新中的作用（实验 2）。大鼠在 A 环境中接受了 45mg 蔗糖丸的固定比例 25（实验 1 和 2）强化时间表的训练。获得后，大鼠分别在 B 环境和 A 环境中进行了消退和 4 次更新测试。在实验 2 中，大鼠在第一次更新测试前 30 分钟接受载体或 D2 多巴胺受体拮抗剂 eticlopride（5、10、20 或 40μg/kg）预处理。后续实验（实验 3）研究了高剂量 eticlopride（40μg/kg）对运动活动的影响。蔗糖寻求行为的更新持续了 3 个会话。Eticlopride 呈剂量依赖性地阻断了蔗糖寻求行为的更新，而不抑制运动活动，表明 D2 多巴胺受体在介导蔗糖寻求行为的更新中发挥作用。
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