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Psychopharmacology (Berl). 2008 Apr;197(2):247-61. doi: 10.1007/s00213-007-1026-2. Epub 2007 Dec 27.
2
Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues.伏隔核核心或壳区多巴胺D1家族受体阻断对情境和离散线索诱导的海洛因觅药复燃的不同影响。
J Neurosci. 2007 Nov 14;27(46):12655-63. doi: 10.1523/JNEUROSCI.3926-07.2007.
3
Effects of opioid receptor blockade on the renewal of alcohol seeking induced by context: relationship to c-fos mRNA expression.阿片受体阻断对由环境诱导的觅酒行为恢复的影响：与c-fos mRNA表达的关系。
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The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking.D1多巴胺受体在消退的觅酒行为恢复中的神经关联及作用
Neuroscience. 2007 May 11;146(2):525-36. doi: 10.1016/j.neuroscience.2007.01.063. Epub 2007 Mar 23.
5
Behavioral and neuropharmacological characterization of nicotine as a conditional stimulus.尼古丁作为条件刺激的行为学和神经药理学特征
Eur J Pharmacol. 2007 Apr 30;561(1-3):91-104. doi: 10.1016/j.ejphar.2007.01.046. Epub 2007 Feb 1.
6
The debate over dopamine's role in reward: the case for incentive salience.关于多巴胺在奖赏中作用的争论：动机显著性的实例
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The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats.代谢型谷氨酸受体2/3激动剂LY379268可减弱大鼠中由环境和离散线索诱导的蔗糖寻求行为的恢复，但对蔗糖自身给药行为无此作用。
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The ethanol self-administration context as a reinstatement cue: acute effects of naltrexone.作为复吸线索的乙醇自我给药情境：纳曲酮的急性效应
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Neurobiology of relapse to heroin and cocaine seeking: an update and clinical implications.海洛因和可卡因成瘾复发的神经生物学：最新进展及临床意义。
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大鼠蔗糖觅药行为的恢复：D2 多巴胺受体的作用。

Renewal of sucrose-seeking behavior in rats: Role of D(2) dopamine receptors.

机构信息

Department of Psychology, James Hall, Dickinson College, Carlisle, PA 17013, USA.

出版信息

Pharmacol Biochem Behav. 2010 Sep;96(3):354-62. doi: 10.1016/j.pbb.2010.06.006. Epub 2010 Jun 17.

DOI:10.1016/j.pbb.2010.06.006
PMID:20600249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2908712/
Abstract

The present study characterized renewal of sucrose-seeking behavior in rats (Experiment 1). The role of the dopamine subtype-2 (D(2)) receptors in mediating renewal of sucrose-seeking behavior also was examined (Experiment 2). Rats were trained to respond for sucrose pellets (45mg each) on a fixed-ratio 25 (Experiments 1 and 2) schedule of reinforcement in Context A. Following acquisition, rats underwent extinction and 4 renewal tests in Contexts B and A, respectively. In Experiment 2, rats were pretreated with vehicle or the D(2) dopamine receptor antagonist eticlopride (5, 10, 20, or 40microg/kg) 30min prior to the first renewal test session. A follow-up experiment (Experiment 3) examined the effect of a high eticlopride dose (40microg/kg) on locomotor activity. Renewal of sucrose-seeking behavior persisted for 3 sessions. Eticlopride dose-dependently blocked renewal of sucrose-seeking behavior without suppressing locomotor activity, implicating a role of D(2) dopamine receptors in mediating renewal of sucrose-seeking behavior.

摘要

本研究描述了大鼠中蔗糖寻求行为的更新（实验 1）。还研究了多巴胺 D2 受体亚型在介导蔗糖寻求行为更新中的作用（实验 2）。大鼠在 A 环境中接受了 45mg 蔗糖丸的固定比例 25（实验 1 和 2）强化时间表的训练。获得后，大鼠分别在 B 环境和 A 环境中进行了消退和 4 次更新测试。在实验 2 中，大鼠在第一次更新测试前 30 分钟接受载体或 D2 多巴胺受体拮抗剂 eticlopride（5、10、20 或 40μg/kg）预处理。后续实验（实验 3）研究了高剂量 eticlopride（40μg/kg）对运动活动的影响。蔗糖寻求行为的更新持续了 3 个会话。Eticlopride 呈剂量依赖性地阻断了蔗糖寻求行为的更新，而不抑制运动活动，表明 D2 多巴胺受体在介导蔗糖寻求行为的更新中发挥作用。