Qi X G
Third Hospital Affiliated to China Medical University, Shenyang.
Zhong Xi Yi Jie He Za Zhi. 1991 Feb;11(2):102-4, 69.
Experimental model of acute liver damage with D-galactosamine was made. Thereafter, Salvia miltiorrhiza (SM) and Paeonia lactiflora (PL) were given to the rats. Survival rate of rats and liver coefficient (liver weight/body weight) were observed. Changes of ALT and bilirubin in serum were detected. Level of plasma fibronectin (PFN) was determined at various times. Changes of pathological histology under microscope and electron-microscope were observed. The results showed that SM and PL could increase plasma fibronectin levels in rats, and improve the reticuloendothelial system function and plasma opsonic activity. Aggregation of microaggregated albumin, collagen fragment and immune complexes were markedly reduced. Liver immune damage and microcirculation disorder were avoided. Meanwhile, PFN could cause increase of phagocytosis of Kupffer cell to endotoxin. It is concluded that SM and PL play an important role in protective hepatocyte.
建立了D-半乳糖胺致急性肝损伤的实验模型。此后，将丹参（SM）和白芍（PL）给予大鼠。观察大鼠的存活率和肝系数（肝脏重量/体重）。检测血清中ALT和胆红素的变化。在不同时间测定血浆纤维连接蛋白（PFN）水平。观察显微镜和电子显微镜下病理组织学的变化。结果表明，SM和PL可提高大鼠血浆纤维连接蛋白水平，改善网状内皮系统功能和血浆调理活性。微聚集白蛋白、胶原片段和免疫复合物的聚集明显减少。避免了肝脏免疫损伤和微循环障碍。同时，PFN可使库普弗细胞对内毒素的吞噬作用增强。结论：SM和PL在保护肝细胞方面起重要作用。
