Cheng Y Y, Fong S M, Hon P M, Li C M, Chang H M
Chinese Medicinal Material Research Centre, Chinese University of Hong Kong.
Zhong Xi Yi Jie He Za Zhi. 1991 Sep;11(9):543-6, 518.
Acute fatal ventricular fibrillation (VF) in male Sprague-Dawley rats was induced by subcutaneous injection of isoproterenol (1 mg or 5 mg/kg body weight) to two groups of rats of different body weights (525 +/- 21 g or 387 +/- 11 g) respectively. VF occurred in all control rats resulting in 96% death with only 4% spontaneously reverted and survived. Pretreatment of animals, with or without pentobarbital anaesthesia, with an aqueous extract of Salvia miltiorrhiza (SM-H, i.p., 5 g herb/kg body weight) significantly reduced J-point displacement and VF induced by isoproterenol. Survival rate was significantly raised compared with the control (P less than 0.05). Immediate intravenous injection of SM-H (5 g herb/kg body weight) to poisoned rats which developed VF caused 71% of them to recover temporarily their sinus rhythm and significantly prolonged their survival time (P less than 0.05).
分别对两组不同体重（525±21克或387±11克）的雄性Sprague-Dawley大鼠皮下注射异丙肾上腺素（1毫克或5毫克/千克体重），诱发急性致命性心室颤动（VF）。所有对照大鼠均发生心室颤动，导致96%死亡，仅4%自发恢复并存活。对动物进行预处理，无论是否使用戊巴比妥麻醉，给予丹参水提取物（SM-H，腹腔注射，5克生药/千克体重），可显著降低异丙肾上腺素诱导的J点位移和心室颤动。与对照组相比，存活率显著提高（P<0.05）。对发生心室颤动的中毒大鼠立即静脉注射SM-H（5克生药/千克体重），导致71%的大鼠暂时恢复窦性心律，并显著延长其存活时间（P<0.05）。
