Department of Pathology, Bacteriology and Avian Diseases, Research Group Veterinary Public Health and Zoonoses, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
Vaccine. 2010 Aug 16;28(36):5920-3. doi: 10.1016/j.vaccine.2010.06.035. Epub 2010 Jul 16.
Necrotic enteritis is an economically important disease of chickens caused by Clostridium perfringens. Immunity to necrotic enteritis is not fully characterized yet, but previous reports indicate that immunoprotective potential is present in the secreted component of C. perfringens. This study aimed to compare the vaccine potential of the supernatants of eight chicken strains of C. perfringens differing in origin, level of alpha toxin production and presence of netB gene. The supernatant of only one strain provided full protection, while one other strain provided partial protection against a severe infection challenge. Our results indicate that the protective characteristics of the supernatants are not solely based on the presence of NetB or alpha toxin.
坏死性肠炎是由产气荚膜梭菌引起的一种对鸡具有重要经济意义的疾病。坏死性肠炎的免疫机制尚未完全阐明，但先前的报告表明，产气荚膜梭菌的分泌成分具有免疫保护潜力。本研究旨在比较 8 株来源、α 毒素产生水平和 netB 基因存在差异的鸡源产气荚膜梭菌上清液的疫苗潜力。只有一株菌的上清液能提供完全保护，而另一株菌的上清液能对严重感染挑战提供部分保护。我们的结果表明，上清液的保护特性不仅基于 NetB 或 α 毒素的存在。
