Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Neurosci Lett. 2010 Sep 6;481(2):97-101. doi: 10.1016/j.neulet.2010.06.060. Epub 2010 Jun 26.
Deep brain stimulation (DBS) is now emerging as a new option for treating intractable epilepsy. Cumulative studies suggest that the mediodorsal thalamic nucleus (MD) is involved in limbic seizure activity. This study aims to investigate whether DBS of the MD can protect against seizures induced by amygdaloid kindling. We studied the effect of low-frequency stimulation (LFS, 1 Hz) or high-frequency stimulation (HFS, 100 Hz) in the MD on amygdaloid kindling seizures. During the kindling acquisition, DBS in the MD was daily administered immediately after the kindling stimulus or before the kindling stimulus (preemptive DBS). The effects of both post-treatment of DBS and preemptive DBS in the MD on the expression of amygdaloid kindling seizures were evaluated. We found the DBS or preemptive DBS in the MD, either LFS or HFS, did not significantly change the rate of amygdaloid kindling. Similarly, DBS or preemptive DBS in the MD did not significantly change any parameters representing the expression of amygdaloid kindling. Our study suggests that DBS in the MD may have no significant effect on limbic seizures.
深部脑刺激（DBS）现在作为治疗难治性癫痫的新选择出现。累积研究表明，中脑背内侧核（MD）参与边缘性癫痫发作活动。本研究旨在探讨 MD 的 DBS 是否可以预防杏仁核点燃诱导的癫痫发作。我们研究了 MD 中的低频刺激（LFS，1 Hz）或高频刺激（HFS，100 Hz）对杏仁核点燃发作的影响。在点燃获得期间，MD 中的 DBS 在点燃刺激后或在点燃刺激前（预防性 DBS）每天给予。评估了 MD 中的 DBS 或预防性 DBS 对杏仁核点燃发作的表达的后处理和预防性 DBS 的影响。我们发现 MD 中的 DBS 或预防性 DBS（无论是 LFS 还是 HFS）均未显著改变杏仁核点燃的速率。同样，MD 中的 DBS 或预防性 DBS 也未显著改变代表杏仁核点燃表达的任何参数。我们的研究表明，MD 中的 DBS 可能对边缘性癫痫发作没有明显影响。
