Department of Etiology and Immunology, Hunan University of TCM, Shaoshan Road, Changsha, Hunan 410007, PR China.
J Ethnopharmacol. 2010 Aug 19;131(1):130-4. doi: 10.1016/j.jep.2010.06.014. Epub 2010 Jun 17.
Qiwei Baizhu Powder (QWBZP) is a traditional herbal prescription that has been used traditionally for the treatment of infantile diarrhea, including the infantile diarrhea caused by Human Rotavirus (HRV). In this study, we investigated the pharmacological activity of QWBZP extract.
NIH suckling mice with HRV induced diarrhea were used. Density of CD3(+), CD4(+) and CD8(+) T cells, mRNA expression of IL-2, IFN-gamma, IL-4 and IL-10 in intestinal mucosa epithelial cells were assayed.
QWBZP extract promoted the expressions of mRNA of IL-2, IL-4, IL-10 and IFN-gamma in intestinal mucosa epithelial cells. Also, we found that the density of CD8(+) cells in intestinal mucosa epithelial cells was significantly lower in QWBZP group than in Model group, while the density of CD8(+) cells was significantly higher in QWBZP group than in Model group.
These data suggest that QWBZP extract may exhibit antiviral effects through modulating the densities of T-cell subsets and the expressions of their cytokines in small intestinal mucosa epithelial cells.
七味白术散（QWBZP）是一种传统的中草药方剂，传统上用于治疗小儿腹泻，包括轮状病毒（HRV）引起的小儿腹泻。在这项研究中，我们研究了 QWBZP 提取物的药理活性。
用人轮状病毒诱导的 NIH 乳鼠腹泻模型进行研究。测定肠道黏膜上皮细胞中 CD3(+)、CD4(+)和 CD8(+)T 细胞的密度、IL-2、IFN-γ、IL-4 和 IL-10 的 mRNA 表达。
QWBZP 提取物促进了肠道黏膜上皮细胞中 IL-2、IL-4、IL-10 和 IFN-γmRNA 的表达。此外，我们发现 QWBZP 组肠道黏膜上皮细胞中 CD8(+)细胞的密度明显低于模型组，而 QWBZP 组肠道黏膜上皮细胞中 CD8(+)细胞的密度明显高于模型组。
这些数据表明，QWBZP 提取物可能通过调节小肠黏膜上皮细胞中 T 细胞亚群的密度及其细胞因子的表达来发挥抗病毒作用。
