Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong, China.
Drug Discov Today. 2010 Aug;15(15-16):622-9. doi: 10.1016/j.drudis.2010.06.011. Epub 2010 Jun 25.
The Rho/rho-kinase (ROCK) pathway has an important role in the pathogenesis of several cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular tone, endothelial dysfunction, inflammation and remodeling. The inhibition of ROCK has a beneficial effect in a variety of cardiovascular disorders. Evidence from animal models and from clinical use of ROCK inhibitors, such as Y-27632, fasudil and statins (i.e. pleiotropic effects), supports the hypothesis that ROCK is a potential therapeutic target. This review provides a current understanding of the role of ROCK pathway in the regulation of vascular function and the use of ROCK inhibitors in the treatment of cardiovascular disorders.
Rho/ rho-kinase (ROCK) 通路在多种心血管疾病的发病机制中具有重要作用。ROCK 的激活参与了血管张力、内皮功能障碍、炎症和重塑的调节。ROCK 的抑制在多种心血管疾病中具有有益的作用。来自动物模型和 ROCK 抑制剂（如 Y-27632、法舒地尔和他汀类药物，即多效性作用）的临床应用的证据支持 ROCK 是一个潜在的治疗靶点的假说。这篇综述提供了对 ROCK 通路在血管功能调节中的作用以及 ROCK 抑制剂在心血管疾病治疗中的应用的最新认识。
