25-羟维生素 D 和离子钙对甲状旁腺激素分泌的调节取决于维生素 D 状态：一项在大量健康受试者中进行的研究。

Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status: a study in a large cohort of healthy subjects.

机构信息

Unit of Internal Medicine, Casa Sollievo della Sofferenza Hospital, I.R.C.C.S., San Giovanni Rotondo (FG), Italy.

出版信息

Bone. 2010 Sep;47(3):626-30. doi: 10.1016/j.bone.2010.06.013. Epub 2010 Jun 19.

DOI:10.1016/j.bone.2010.06.013

PMID:20601288

Abstract

INTRODUCTION

Previous papers investigating vitamin D status have often outlined the significant relationships between serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD), but the influence of ionized calcium levels has not been concomitantly considered.

DESIGN

Cross-sectional.

MATERIALS AND METHODS

In 1050 healthy men (547) and women (503), serum ionized calcium (iCa), creatinine (Cr), albumin, 25OHD, and PTH were measured. After conventional analysis, a regression tree was fitted on the data set.

RESULTS

25OHD and PTH values showed significant opposite seasonal changes. 25OHD levels negatively correlated with PTH, which in turn negatively correlated with iCa. A regression tree was fitted to the whole data set using PTH as the response variable and 25OHD and iCa as covariates. PTH concentration depended on that of iCa only in subjects with 25OHD levels>16.35 ng/mL, while for 25OHD<16.35 ng/mL it depended on 25OHD values.

CONCLUSIONS

Our results indicated that PTH levels were highly conditioned by those of 25OHD in subjects with 25OHD values lower than 16.35 ng/mL and by those of iCa only for higher 25OHD concentration.

摘要

简介

之前研究维生素 D 状态的论文经常概述了血清甲状旁腺激素 (PTH) 和 25-羟维生素 D (25OHD) 之间的显著关系，但同时没有考虑到离子钙水平的影响。

设计

横断面研究。

材料和方法

在 1050 名健康男性（547 名）和女性（503 名）中，测量了血清离子钙 (iCa)、肌酐 (Cr)、白蛋白、25OHD 和 PTH。在常规分析后，将回归树拟合到数据集上。

结果

25OHD 和 PTH 值显示出明显的相反季节变化。25OHD 水平与 PTH 呈负相关，而 PTH 又与 iCa 呈负相关。使用 PTH 作为响应变量，25OHD 和 iCa 作为协变量，对整个数据集进行了回归树拟合。只有在 25OHD 水平>16.35ng/mL 的受试者中，PTH 浓度取决于 iCa 的浓度，而对于 25OHD<16.35ng/mL 的受试者，PTH 浓度取决于 25OHD 值。