Orskov H, Christensen S E, Weeke J, Kaal A, Harris A G
Medical Research Laboratories, University of Aarhus, Denmark.
Clin Endocrinol (Oxf). 1991 May;34(5):395-8. doi: 10.1111/j.1365-2265.1991.tb00311.x.
Two patients developed specific IgG antibodies against octreotide after 2-3 years' treatment for acromegaly with this long acting somatostatin analogue. The presence of these antibodies reduced the plasma disappearance rate of total extractable octreotide by 60 and 80% respectively. When compared to that of non-immune acromegalic patients, the plasma half-life of octreotide in these two patients was 300 and 450 vs 110 min in those with no detectable octreotide antibodies. The sole observed consequence of the immunization was a marked prolongation of the interval of maximum GH inhibition from a mean of 5 to 8 and 10 h in the two patients described after octreotide injection.
两名肢端肥大症患者在使用这种长效生长抑素类似物治疗2至3年后，产生了针对奥曲肽的特异性IgG抗体。这些抗体的存在分别使总可提取奥曲肽的血浆清除率降低了60%和80%。与未产生免疫反应的肢端肥大症患者相比，这两名患者体内奥曲肽的血浆半衰期分别为300分钟和450分钟，而未检测到奥曲肽抗体的患者血浆半衰期为110分钟。免疫反应唯一观察到的结果是，在上述两名患者中，奥曲肽注射后最大程度抑制生长激素的时间间隔显著延长，从平均5小时延长至8小时和10小时。
