Department of Epidemiology and Public Health, University College Cork, Ireland.
Sex Transm Dis. 2010 Oct;37(10):602-7. doi: 10.1097/OLQ.0b013e3181e1a296.
Expedited partner therapy (EPT) has been shown to reduce the risk of persistent or recurrent gonorrhea and chlamydial infection in heterosexuals, and to increase the proportion of sex partners receiving treatment. The objective of this analysis was to evaluate the consistency of EPT's effect across sociodemographic and behavioral subgroups.
Subset analyses from a randomized controlled trial compared EPT to standard partner referral (SPR) in sociodemographic and behaviorally defined subgroups. Outcomes included persistent or recurrent infection in study participants and participants' report that their partners received treatment.
Reinfection risk was lower among EPT recipients than nonrecipients in 21 of 22 subgroups, with relative risks (RRs) varying from 0.4 to 0.94. Compared to persons receiving SPR, persons receiving EPT were more likely to report that their partners were very likely to have been treated in 33 of 34 subgroups (RRs range, 1.03-1.36). Although EPT reduced the risk of persistent or recurrent infection somewhat more in men (RR, 0.56; 95% CI, 0.3-1.08) than in women (RR, 0.81; 95% CI, 0.61-1.07) and more in persons with gonorrhea (RR, 0.32; 95% CI, 0.13-0.78) than those with chlamydial infection (RR, 0.82; 95% CI, 0.63-1.07), the RR of partners being treated associated with EPT was similar in men (RR, 1.21; 95% CI, 1.05-1.39) and women (RR, 1.18; 95% CI, 1.10-1.27), and also in persons with gonorrhea (RR, 1.33; 95% CI, 0.80-2.23) and chlamydial infection (RR, 1.33; 95% CI, 1.07-1.66).
In this study, EPT is shown to be superior to SPR across a wide spectrum of sociodemographic and behaviorally defined subgroups.
已证实，性伴通知治疗（EPT）可降低异性恋者持续性或复发性淋病和衣原体感染的风险，并增加接受治疗的性伴比例。本分析的目的是评估 EPT 效果在社会人口统计学和行为学亚组中的一致性。
一项随机对照试验的亚组分析比较了 EPT 与标准性伴转诊（SPR）在社会人口统计学和行为定义的亚组中的效果。结局包括研究参与者的持续性或复发性感染以及参与者报告其性伴接受治疗的情况。
在 22 个亚组中的 21 个中，EPT 组的再感染风险低于非 EPT 组，相对风险（RR）范围为 0.4 至 0.94。与接受 SPR 的人相比，报告其性伴极有可能接受治疗的 EPT 组参与者在 34 个亚组中的 33 个亚组中（RR 范围，1.03-1.36）更多。尽管 EPT 使男性（RR，0.56；95%CI，0.3-1.08）而非女性（RR，0.81；95%CI，0.61-1.07）持续性或复发性感染的风险降低的幅度略大，且使淋球菌感染者（RR，0.32；95%CI，0.13-0.78）而非衣原体感染者（RR，0.82；95%CI，0.63-1.07）的感染风险降低的幅度略大，但 EPT 与伴侣接受治疗的 RR 在男性（RR，1.21；95%CI，1.05-1.39）和女性（RR，1.18；95%CI，1.10-1.27）中相似，也在淋球菌感染者（RR，1.33；95%CI，0.80-2.23）和衣原体感染者（RR，1.33；95%CI，1.07-1.66）中相似。
在这项研究中，EPT 在广泛的社会人口统计学和行为学定义的亚组中均优于 SPR。
